Simvastatinum [Latin]

Simvastatinum [Latin] Brand names, Simvastatinum [Latin] Analogs

Simvastatinum [Latin] Brand Names Mixture

No information avaliable

Simvastatinum [Latin] Chemical_Formula

C₂₅H₃₈O₅

Simvastatinum [Latin] RX_link

http://www.rxlist.com/cgi/generic/simva.htm

Simvastatinum [Latin] fda sheet

Simvastatinum_[Latin] FDA

Simvastatinum [Latin] msds (material safety sheet)

Simvastatinum [Latin] Synthesis Reference

W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)

Simvastatinum [Latin] Molecular Weight

418.566 g/mol

Simvastatinum [Latin] Melting Point

135-138^oC

Simvastatinum [Latin] H₂O Solubility

0.76 mg/L

Simvastatinum [Latin] State

Solid

Simvastatinum [Latin] LogP

4.937

Simvastatinum [Latin] Dosage Forms

Tablet (oral)

Simvastatinum [Latin] Indication

For the treatment of hypercholesterolemia.

Simvastatinum [Latin] Pharmacology

Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.

Simvastatinum [Latin] Absorption

Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.

Simvastatinum [Latin] side effects and Toxicity

No information avaliable

Simvastatinum [Latin] Patient Information

Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.

Simvastatinum [Latin] Organisms Affected

Humans and other mammals